McCaw Hall is located on Mercer Street between 3rd and 4th Avenues, on the north edge of the Seattle Center campus, approximately 2 miles north of the Downtown Seattle business district. The Hall's street address is 321 Mercer Street.

From I-5: Take Mercer Street exit and take right at light. Take left at next light onto Valley and follow into Broad Street. Turn right on Harrison, right on 5th, left on Roy and left onto 3rd Ave. Turn left to park in the Seattle Center Mercer Street Garage, or proceed to the corner of 3rd and Mercer, turn left (Mercer is one-way east-bound) and proceed immediately to the far right lane to drop off patrons directly in front of McCaw Hall.